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Anekwe highlights that "some research shows GLP-1s may slow cognitive decline and have a role in neuroprotection." Addiction treatment
This selectivity means tanning effects are achieved with limited activation of MC3R, MC4R, and MC5R the receptors responsible for off-target effects such as libido modulation (MC4R), appetite suppression (MC4R/MC3R), and sebaceous gland activity (MC5R)
Clinical stage: Currently in Phase 3 clinical trials (SYNCHRONIZE program) for obesity, with or without type 2 diabetes, and separate late-stage studies for MASH
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