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Individual heartbeats were determined by identifying local maxima using a 1D data peak detection algorithm (peakutils.peak)

If additional validation of acetylcarnitine is carried out in a follow-up study, taking into account the larger sample size, controlled subject variables, antidepressant type, and heterogeneity due to pharmacomechanism, the potential of acetylcarnitine as a biomarker for diagnosing depression and remission status will be further elucidated

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Research comparing these approaches head-to-head remains limited, leaving the choice to researcher preference and practical considerations