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How Does Adding Glucagon Change the Mechanism
A study in the Journal of the American Geriatrics Society showed benefits
While GLP-1 RAs have provided an important new weapon for those suffering from profound obesity, they unfortunately trigger the same counter-productive mechanisms as other weight-loss efforts, which rely on caloric restriction, resulting in muscle loss, which limits the fat loss and metabolic benefit
Faster rates, while sometimes achievable short term, rarely sustain long term and may indicate excessive caloric restriction that will trigger metabolic adaptation
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