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SULFATION SAFE PATHWAY (SULT enzymes) 30-35% of acetaminophen in healthy non-pregnant adults Attaches sulfate groups for safe elimination Non-toxic pathway DECREASES 33% during pregnancy (contrary to previous assumptions)[] Limited capacityeasily saturated with repeated doses Predominant pathway in fetuses/children (60-70%) but quickly overwhelmed 3
Obesity (Silver Spring), 30(6), 10401051
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