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However, in a much larger randomized controlled trial of simvastatin and an antioxidant combination of 600 mg of all - rac --tocopherol (297 mg of RRR --tocopherol), 250 mg of vitamin C, and 20 mg of -carotene daily) in more than 20,000 men and women with CHD or diabetes mellitus, the antioxidant combination did not adversely affect the cardioprotective effects of simvastatin therapy over a five-year period (131)

After accounting for gender differences, the subjects were further stratified into age groups

Catechins also enhance the activity of endogenous antioxidant enzymes like superoxide dismutase (SOD) and catalase, bolstering the bodys ability to neutralize ROS [210, 211]

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