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The SABR trial 43 (NCT02992912) is a phase II, multicenter study designed to evaluate the efficacy and safety of combining the PD-L1 ICI atezolizumab with stereotactic body radiation therapy in patients with metastatic (stage IV) CRC
GLP-1 medications reduce saliva production through direct receptor activation in salivary glands, independent of overall body hydration
The alleged joint pain could be due to Ozempics effects on GLP-1 receptors in the joints or tissues surrounding the joint, while others suggest that another type of GLP-1 agonist triggered the joint pain or that acute kidney injury and pancreatitis both rare but serious side effects of Ozempic can cause fluid accumulation in the joints, which does cause pain in the joints
Lippi G, Salvagno GL, Targher G, Montagnana M, Guidi GC
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