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In murine models of dextran sulfate sodium (DSS)-induced colitis, pharmacological FXR activation attenuates epithelial damage, reduces FITC-dextran leakage, and preserves mucosal architecture, whereas FXR deficiency exacerBAstes inflammation and BAsrrier dysfunction ( Other nuclear receptors broaden this transcriptional defense network by sensing hydrophobic or potentially toxic BAs metabolites and inducing detoxification-related programs
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In healthy people who lose weight gradually (through diet and/or exercise), about 25% of the weight loss is LBM and 75% is fat
When that went away, I think the real me kind of came out, and then I started to become taken more seriously. For HR people navigating this domain, Frahn suggests education and awareness
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