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Body weight reduction: 2.3 to 4.4 kg depending on dose and background therapy

The peptide successfully heals internal fistulas (gastrocutaneous, duodenocutaneous, and colocutaneous) in experimental models, achieving fistula closure even when treatment is delayed for one month after fistula formation

Similar effects have been demonstrated in rodent MSC, where treatment with Ex at 10ng/ml 2.4 nM led to upregulation of pancreatic genes such as PDX-1 , GLUT2 and Insulin as well as an increase in DTZ-positive cells [53, 54]

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