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Clinical outcomes associated with anti-obesity medications in real-world practice: A systematic literature review
Rapid Risk Reduction Seen in First Months The study found that semaglutide was associated with a 38% reduced risk of major adverse cardiovascular events (MACE) within the first 3 months compared to placebo (36 vs 58, respectively) Within the first 6 months, semaglutide was associated with a 41% reduced risk of MACE compared to placebo (67 vs 113, respectively) Notably, at 3 and 6 months, most patients had not yet lost much weight and many were not yet on the full target dose of semaglutide 2.4 mg weekly
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Mild to moderate nausea, constipation, fatigue, and appetite loss fall within expected adjustment symptoms and typically improve with time and lifestyle modifications
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