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Prog Neuropsychopharmacol Biol Psychiatry 46:200206

Although still exploratory, these findings suggest that the Kyn/Trp ratio may warrant further evaluation as a potential marker for risk stratification in longitudinal studies

A 2025 systematic review in the International Journal of Dermatology documented liver function abnormalities in approximately half of IV-treated participants at high doses, which is why DermaVue restricts treatment to evidence-based clinical doses of 400 to 1200 mg with mandatory hepatic monitoring

One of the side effects that have been reported is quite similar to other injectable incretin-based therapies