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SUSCEPTIBILIDAD A LAS DROGAS La biotransformacin heptica de las drogas comienza en el retculo endoplasmtico con la oxidacin por el citocromo P450 seguida de la conjugacin por las enzimas n-acetiltransferasa y glutationtransferasa, que produce metabolitos, denominados haptenos, que son ligados, posteriormente, a las protenas del hepatocito
Minimize contact with oxygen during storage and handling as oxidation can affect peptide stability
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N Engl J Med 343(3):180184
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