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Common Drug Interactions with GLP-1s Prescriptions to monitor include: Thyroid meds (like levothyroxine): delayed absorption = wonky labs Oral birth control : less reliable if not absorbed well (oops!) SSRIs/SNRIs : altered absorption can lead to mood changes Fat-soluble vitamins (A, D, E, K) : need bile flow and good digestion Iron/B12 : absorption requires stomach acid, which may be reduced PPIs (Prilosec, Nexium) : when combined with GLP-1s, can severely limit nutrient uptake Over-the-Counter Medications to Watch Even common OTC meds can cause problems when combined with GLP-1s

Variants in GIPR gene (rs1800437) show measurable associations with GLP-1 efficacy and side-effect profile

Our article on electrolytes on semaglutide explains why hydration can take a little extra effort