The TGA reports a number of adverse events and other concerns received for unapproved peptide products, which include: severe allergic reactions, requiring doses of adrenaline and hospitalisation systemic inflammatory response syndrome (SIRS) (severe inflammation in the body), requiring hospital management generalised hypersensitivity symptoms such as fullbody intense itching, palpitations, pain and sweating wide ranging body side effects, including insomnia, blurred vision, extreme tiredness, flulike illness, joint pain and skin sensitivity musculoskeletal injuries, including plantar fasciitis and Achilles tendinitis, and poor product quality, including unsealed packaging from an online supplier
Also, since SGLT-2 inhibitors are also known to have significant CV benefits, studies with more SGLT-2 inhibitor use in the comparator arm could have prevented the ability to detect a difference produced by the study GLP-1 RA
Well focus on the gut, our immune system and the brain, or more simply whats called the Gut-Immune-Brain axis
These observations are consistent with the mechanistic picture but have not yet been tested in dedicated randomized controlled trials