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Enhanced resistance to viruses in nicotiana edwardsonii ColumbiaIs dependent on salicylic acid, correlates with high glutathione levels, and extends to plant-pathogenic bacteria and abiotic stress

However, this conversion process depends on the availability of two other amino acids (cysteine and glycine) and various enzymes

On that test, an NNMT inhibitor plus an NAD+ precursor is at least internally coherent one addresses the drain, the other the supply while pairing 5-Amino-1MQ with an unrelated appetite-acting compound is not synergy, it is simply two separate interventions being run at once