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Taken together, these observations suggest that except in vitamin B 12 deficiency (which only responds to cyanocobalamin treatment because of the inactivation of methionine synthase), folate treatment should be the most adequate therapy to reverse hyperhomocysteinemia detected both under basal conditions and after an oral methionine load
synthesized by certain bacteria Although the intestinal flora of humans is able to synthesize vitamin B 12 , humans are not able to absorb bacteria-generated vitamin B 12 since the location of synthesis (the colon) is too distal from the location of absorption (the small intestine)
PIONEER program: Oral semaglutide in diabetes
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