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Exploring autoimmune conditions The application of oncology-proven CAR-T constructs targeting CD19, CD20 or BCMA, for B-cell mediated, autoimmune conditions is the most notable trend
Of medical importance, the discovery of the DPP-4 protease resistant exendin-4 from venom of Heloderma suspectum paved the way for the successful development of GLP-1 analogues as important treatments for insulin resistant type 2 diabetics
While multi-agonism with incretin hormones and glucagon has demonstrated great therapeutic potential, the conceptual approach of polypharmacology has also been extended to other hormone combinations
Cell 72 , 971983 (1993)
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