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PDI has two active sites, both of which are characterized by the presence of a CGHC motif, which either forms a disulphide for the enzyme to become active as an oxidase, or a dithiol for the enzyme to act as an isomerase
The brain response to natural GLP-1 stimulation is subtle compared to medications
So, as dermatologists, we have to keep an eye out for new developing acne in patients on these medications, counsel our patients first and foremost and then be ready to treat the acne. Tolkachjov recommends that if an adult woman on a GLP-1 receptor agonist comes into the clinic reporting sudden acne, try to treat the acne with topicals first unless inflammatory or scarring acne is present, working up to isotretinoin if necessary
Ethics of organoid research
