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5-Amino-1MQ selectively inhibits nicotinamide N-methyltransferase (NNMT), a methyltransferase enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide
Interestingly, astrocyte reactivity is influenced and modulated by microglia activation, suggesting that drugs targeting microglia may offer an indirect strategy to combat reactive astrocytes
Individual responses may vary, and IV hydration is not intended to replace medical care for ongoing conditions
10.1136/archdischild-2023-326049 17 DagherM.CahillC
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