increased heart rate with tirzepatide How the weight loss drug is also helping failure patients UC Irvine researchers project cardiac

The effect of tirzepatide on 24-hour mean systolic BP, diastolic BP, and heart rate (HR) measured during 24-hour ambulatory BP monitoring (ABPM) in individuals living with obesity without T2DM, has been evaluated in the SURMOUNT-1 ABPM sub-study.34 After 36 weeks of treatment, tirzepatide was associated with statistically significant and clinically meaningful reductions in the mean 24-hour systolic BP at all doses and reduced diastolic BP at the 2 lower doses.34 Simultaneously, tirzepatide treatment was associated with a dose-dependent increase in the mean 24-hour HR.34 Fortunately, there is no clear evidence that tirzepatide increases the risk of atrial fibrillation.35 5

For weight loss, semaglutide works by mimicking the hormone GLP-1, which is released when you eat, signalling to your brain that you feel full

This class of medications (similar medications to semaglutide) has been approved since 2005 for the treatment of diabetes

Seminal studies by Knop et al