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Serious ADR on long term use are Vitamin B12 deficency that leads to the anemia, lethergy along with numbness and tingling sensation in hands and feet, lactic acidosis in renal and hepatic impairment
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The classic MIC formulation combines three of them: Methionine an essential amino acid, a methyl donor, and a precursor in the pathways that package hepatic lipid for export
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