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More serious but less common safety considerations observed across this drug class include a potential risk of pancreatitis, gallbladder-related conditions (such as gallstones/cholelithiasis), and based on animal studies a theoretical concern regarding thyroid C-cell tumours, though this has not been confirmed in human trials
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Understanding how much to take, when to take it and how long to continue using it is essential for achieving noticeable results
In combination with metformin immediate-release and rosiglitazone, sitagliptin provided significant improvements in A1C, FPG, and 2-hour PPG compared to placebo with metformin immediate-release and rosiglitazone (Table 12) at Week 18
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