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These studies indicate that 5-amino-1mq can delay skin fibroblast senescence by regulating NAD+ metabolism, providing a novel intervention target for skin anti-aging research

Research highlights NAD+ Increased cellular NAD+ via nicotinamide pool NNMT Enzyme overexpressed in obese adipose tissue Anti-adip Reduced lipid accumulation and adipocyte differentiation SIRT1 Downstream sirtuin activation via NAD+ elevation Research notes Adipocyte research: In vitro models show reduced lipid accumulation and pre-adipocyte differentiation upon NNMT inhibition

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22, 2004 BioWorld Science Endocrine/metabolic