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Published analyses of that trial and of SURMOUNT-1, a comparable trial of tirzepatide, have put lean tissue at roughly one quarter to 40 percent of total weight lost, depending on the trial and the method used

However, in severe hepatic impairment or cirrhosis, the BNF and SmPC advise caution: the dose interval should be increased to at least every 6 hours, and the maximum daily dose may need to be reduced

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