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Choose semaglutide if: You're sensitive to side effects Semaglutide's slower titration means gentler adaptation
For retatrutide , the 2023 New England Journal of Medicine phase 2 trial used doses of up to 12 mg weekly, with a structured escalation schedule beginning at lower doses and increasing incrementally over a period of weeks
Both hold from starter to max dose
Thus, while GLP-1 worked, it would require constant administration not feasible outside a hospital
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