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In mice GLP-1R is expressed in the atrium of the heart and GLP-1R agonist promotes the secretion of atrial natriuretic peptide [17], which consequently causes diuresis and natriuresis
It also surpassed the performance of a competing drug in the GLP-1 class from Danish pharmaceutical company Novo Nordisk called semaglutide
doi:10.1155/2021/3361309 Tan Y, Liu S, Tang Q
Quick Answer: Zepbound can increase bowel frequency in some patients, with 24-30% experiencing diarrhea, though others may develop constipation due to its variable effects on gastrointestinal motility
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