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In pancreatic -cells [58] and ischaemic coronary vascular cells [59], activating GLP-1R promoted mitochondrial respiration, while in astrocytes, GLP-1R activation suppressed mitochondrial oxidative phosphorylation stimulated by -amyloid peptides [60]
Circulation 140 (7), e294e324
Coverage for tirzepatide-based therapies such as Mounjaro or ZepBound may also vary depending on whether the patient has diabetes or meets eligibility criteria for obesity treatment
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