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When the NNMT enzyme is overactive, its often associated with insulin resistance, a condition where your cells dont respond well to insulin and cant easily take up glucose from your blood
Lu et al., 2023)
A way to explain cell death associated with reduced levels of GSH is ferroptosis, a unique iron-dependent form of non-apoptotic cell death, characterized by lipid peroxidation with ROS accumulation due to GSH peroxidase inactivation and high levels of GSH consumption
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