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Intracerebroventricular (ICV) route Reserved for pointed mechanistic studies

The starting dose of 0.25 mg weekly is intentionally low to help your body adjust to the medication and minimize side effects like nausea

11 Division of Molecular Cardiovascular Biology, Cincinnati Childrens Hospital Medical Center, Cincinnati, Ohio, USA

employed a HFD-induced NAFLD mouse model with hepatocyte-specific ablation of the retinoic acid receptor-related orphan receptor (ROR) (ROR-LKO) to demonstrate that liraglutide alleviated hepatic steatosis via ROR-dependent autophagy activation, thus highlighting another mechanism of autophagy activation by GLP-1RAs [28]