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GSH is exclusively degraded at the extracellular level by cells expressing -glutamyltranspeptidase (GGT), such as those of the hepatobiliary tree and of other organs like the heart, kidney, lungs, pancreas, and seminal vesicles
Some studies have examined whether GLP-1 medications might preserve lean muscle mass during weight loss, which could theoretically maintain higher metabolic rates
Referenced Citations Ahrn, B., et al., Semaglutide induces weight loss in subjects with type 2 diabetes regardless of baseline BMI or gastrointestinal adverse events in the SUSTAIN 1 to 5 trials
Patients and clinicians must therefore rely on theoretical considerations, individual patient factors, and clinical judgment
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