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Some people taking GLP-1 medications may experience digestive side effects, with these being the most common: Nausea, especially at the start or after a dose increase Heartburn or stomach discomfort after meals Constipation, which can occur as the body adjusts Diarrhea, which may be mild or bothersome Vomiting, sometimes along with nausea Most digestive side effects lessen as the body adjusts
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