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The most common gastrointestinal side effects include nausea (17-30% of patients), diarrhea (15-23%), constipation (11-17%), vomiting, and abdominal discomfort
investigated infertile PCOS patients with obesity randomly assigned to metformin 1000 mg BID or to metformin 1000 mg BID combined with low-dose liraglutide 1.2 mg/day for 12 week, and demonstrated that weight, BMI, and WC decreased with both treatments, without significant difference between the two arms [59]
It is the active ingredient in Eli Lilly's Zepbound (weight management indication) and Mounjaro (diabetes indication)
Research published in endocrinology journals has documented this theoretical risk, though clinical data on actual pregnancy rates remain limited
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