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(3) Disruption of membrane integrity: -syn interacts with the Translocase of the Outer Mitochondrial Membrane (TOM) complex (e.g., TOM40, TOM20) and the Voltage-Dependent Anion-Selective Channel 1 (VDAC1), which leads to abnormal membrane permeability (McCarthy et al., 2022)
This is the standard starting dose during the first four weeks of escalation
Notice that once you move past 1.0 mg per week with the 1 mg/mL concentration, you exceed the capacity of a standard 1 mL insulin syringe
Think of it as infrastructureit doesnt build the house, but it protects the foundation
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