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During the 1990s, drug companies were also working on their own GLP-1 agonists
174176 A notably comparable study is the population-based cohort analysis by Gamble et al, 174 which utilized UK databases to assess the incidence of new-onset depression or self-harm among new users of GLP-1RAs and dipeptidyl peptidase-4 inhibitors relative to sulfonylureas
In early tumor stages, M1 macrophages exert anti-tumor effects through pro-inflammatory cytokine production, such as TNF- and IL-1, and antigen presentation, yet their functions are often compromised by immunosuppressive mechanisms within the TME