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It is known to help support the detoxification of environmental pollutants, heavy metals, and other toxins
The first set of FUS/TLS mice express HA-tagged complementay DNAs (cDNAs) encoding wild type or either of the two ALS-linked mutations (R514G and R521C) in human FUS/TLS that are transcribed from a mouse prion promoter (to be reported in detail elsewhere)
Each assay batch includes: system suitability standards (injection reproducibility, carryover check), QC samples at low, medium, and high concentrations, blank matrix controls, NADPH-negative controls (to confirm enzyme-dependent metabolism), and reference compound incubations (e.g., midazolam, testosterone) as positive controls
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