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Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial
TB-500: Modulates actin polymerization, enhances cellular motility, supports angiogenesis, and reduces inflammation through the regulation of cytokine production and promotion of anti-inflammatory macrophage polarization
Commercial tirzepatide products (Mounjaro, Zepbound) use even higher concentrations in their pre-filled injection pens
Finally, mucosal impedance testing is another tool to directly evaluate mucosal integrity, although most studies are limited to the esophagus
