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Because retatrutide loses more total weight faster, a person can lose more absolute muscle even at the same percentage which is precisely why the muscle-preservation levers below matter more, not less, on the strongest compound
In a multicenter, randomized, placebo-controlled dose-finding trial, cagrilintide at doses ranging from 0.3 to 4.5 mg weekly produced dose-dependent weight reductions, with the 4.5 mg dose achieving approximately 10.8% weight loss at 26 weeks compared to 3.0% with placebo
[] Other notable drugs like sibutramine and rimonabant were later withdrawn due to cardiovascular and psychiatric risks
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