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Mechanism and role of endoplasmic reticulum stress in osteosarcoma
Specific Mechanistic Effects Laboratory studies have documented cagrilintide-associated effects, including: Satiety-promoting signaling linked to reduced food intake Delayed gastric emptying , reflected by slowed gastric transit Reduced post-prandial glucagon secretion Enhanced regulation of energy balance Modulation of hypothalamic appetite centers and feeding-behavior circuits These effects arise from activation of the amylin and calcitonin receptors in appetite-regulating brain regions and peripheral metabolic tissues
Lancet 2021 Phase 2 (monotherapy) Lau et al., n=706, 26 weeks
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