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Researchers isolated the fragment because it appeared to carry the repair signaling activity of the larger molecule in a more stable form

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Type I interferon gene response is increased in early and established rheumatoid arthritis and correlates with autoantibody production

OARSI pathological scoring confirmed higher scores in the OA group compared to the sham group, whereas metformin treatment resulted in a numerically lower OARSI score than that of the OA group, although the difference was not statistically significant (Fig