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In OA cartilage tissues and IL-1stimulated chondrocyte models, iron accumulation, elevated levels of lipid peroxidation byproducts such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), and downregulation of the antioxidant enzyme GPX4 have been widely reported (5153)
Bruemmer, noting a range of contributors to obesity that are not proactively addressed, from societal factors to health system and payer factors
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