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NF-B activation upregulates genes involved in cell survival and proliferation, such as PUMA, leading to epithelial cell apoptosis and contributing to UC development ( 3 Components of oxidative stress and their contributions to IBD pathogenesis 3.1 ROS in IBD pathogenesis The superoxide anion (O2), which is produced when molecular oxygen gains one electron, is the most prevalent free radical in human tissues ( NOX1 p
Authors: Harkavyi A, Abuirmeileh A, Lever R, Kingsbury AE, Biggs CS, Whitton PS
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