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Preclinical and clinical programs must therefore not only demonstrate that hydrogels act as spacers and local delivery vehicles, but also define how tumor intrinsic factorsnotably histologic subtype (squamous cell carcinoma (SCC) versus adenocarcinoma (AC)) and HPV statusmodify radiosensitivity and the therapeutic benefit gained from hydrogel-mediated radiosensitization (see Table 3)

Physiologically, this is often the result of sarcopenia (muscle wasting) combined with rapid fat loss in the facial pads

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Yes, for users whose muscle pain is related to injection site reactions, changing injection sites can produce immediate improvement