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Hesperidin and related flavonoids are found in a variety of plants, but especially in citrus fruits, particularly their peels (Umeno 2016
They inhibit Nrf2 translocation into the nucleus and enhance NFB activation promoting inflammation and oxidative damage (Laforge et al., 2020)
For example, patients with a history of Medullary Thyroid Cancer are not appropriate candidates for these treatments
NDIN is different from GRAS (Generally Recognised as Safe), which is usually the route for adding ingredients to conventional foods
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