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Sitagliptin differs in chemical structure and pharmacological action from GLP-I analogues, insulin, sulfonylurea derivatives or meglitinides, biguanides, peroxisome proliferator-activated receptor y-receptor agonists (PPARY), alphaglucosidase inhibitors and amylin analogues

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it gives a strong inch-loss result but typically produces significant swelling, redness and tenderness for three to seven days after each session