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Following 6 wk of ethanol administration, GCLM knockout mice were resistant to alcohol-induced steatosis and exhibited beneficial metabolic and stress responses to chronic ethanol consumption
1:15,000) from LI-COR Biosciences (Lincoln, Nebraska, USA), and scanned using an Odyssey Infrared imaging system (Model 9120, LI-COR Biosciences)
Given NASHs intricate pathogenesiswhere existing therapies typically target single pathways or mechanismsa multi-target, multi-pathway approach may offer a novel direction for developing new potential treatments
Investigation of the mechanisms underlying the beneficial metabolic effects of multi-agonist therapies, conducted in PWA mice, as a genuine model for the metabolic alterations of PCOS 36 , revealed a predominant action in terms of suppression of food intake, with negligible effects in terms of energy expenditure, thermogenic function or locomotor activity
