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It's worth noting that weight loss with GLP-1 receptor agonists typically reduces both fat and lean body mass
Conversely, glucocorticoids have also been shown to suppress oxidative phosphorylation
For years, researchers avoided glucagon activation because glucagon raises blood sugar, which seemed counterproductive for a metabolic medication
While the gastrointestinal effects (nausea, diarrhea, vomiting) are similar to other GLP-1 medications like Wegovy and Mounjaro, retatrutide has one unique finding: dysesthesia (abnormal touch sensations) in 20.9% of patients at the 12mg dose in TRIUMPH-4, and 12.5% at 12mg in the larger TRIUMPH-1 trial
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