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Interestingly, this was not correlated with significant changes in pyruvate and glucose consumption, or glutamine consumption, suggesting the resistant cells were taking up oxidizable substrates for the TCA cycle from other sources such as amino acids or fatty acids (Farge et al., 2017)

BPC-157 is used as an adjunct, not a replacement, for standard post-op care

Vitamin B12 is an essential nutrient that plays a key role in red blood cell formation, neurological function, and energy metabolism

Another major resistance mechanism involves a lineage alteration into AR-indifferent carcinoma such a neuroendocrine which is diagnostically characterized by robust 18 F-FDG uptake and loss of AR signaling