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The workaround many prescribers use: if a non-diabetic patient also has a comorbidity that a GLP-1 drug treats (cardiovascular disease for Wegovy, sleep apnea for Zepbound), the prescriber can request coverage under that indication
These are averages from separate trials, not head-to-head results, and individual outcomes vary widely
Results In HFD-fed mice, PDE5i administration significantly enhanced systemic insulin sensitivity and AKT phosphorylation in gWAT
Total progression from start to maximum dose typically takes 16 weeks, though individual timelines vary based on tolerance
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