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Marks MS, Seabra MC
360 Disulfide formation in proteins is reversible, as two cysteine thiols are oxidized into a linked disulfide via thiol-disulfide exchange or oxygen-dependent reactions, often requiring catalysts such as transition metals or flavin adenine dinucleotide (FAD) due to kinetic barriers
Glucagon is another hormone that raises blood sugar levels, so decreasing it helps maintain better blood sugar control
These GI effects typically improve with continued use and slower dose titration
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