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This C-terminal metabolite of GLP-1 has shown cytoprotective effects in isolated mouse hepatocytes and cells exposed to oxidative stress injury, as indicated by trafficking to the mitochondria and the limiting of stress-induced apoptosis through inhibition of mitochondrial depolarization, cytochrome c release, and caspase activation (11, 42)
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Because it contains phentermine, a stimulant closely related to amphetamines, common side effects include: Increased heart rate Elevated blood pressure Insomnia Dry mouth Constipation Tingling in the hands and feet The topiramate component can cause cognitive issues often described as "brain fog," difficulty concentrating, and mood changes
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