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ERS Clinical Practice Guidelines (2025): The European Respiratory Society updated its management guidelines, issuing a conditional recommendation for the use of mucoactive drugs like NAC in specific NCFB phenotypes, particularly those with high sputum production and frequent exacerbations (94)

Glutamine, but not leucine, was found to activate mTORC1 by a pathway requiring the ADP ribosylation factor-1 GTPase and vacuolar adenosine triphosphatase for mTORC1 translocation and fixation, respectively, to the lysosomal membrane

J Clin Invest 40:981988

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